To avoid these things, you need to check your gain stages in every part of your signal chain and make sure nothing is clipping and/or over-saturating a plugin effect. If you do that, you will not get any cackles when you scream
If it was clipped when recorded, you can re-record it and/or try some restoration processes to get rid of it. some clipping when its done in the recording stage is hard to get rid of and sometimes it cannot
CJ