A few observations from my studio:
The operating system is windows... not always a rock solid OS. Things do go wrong from time to time .... just because.
I don't generally "run out" and buy the latest upgrades and don't always load the updates as they come out.
My current DAW is running XP pro/32 and X1 essentials (no updates) and is not internet connected. It runs pretty much like the day I first turned it on after I built it myself.
If I load X1, and while working in my project, I notice that the generally smooth operation of X! starts to become erratic in any way..... audio glitches or a cursor that starts to get a bit "jumpy"... I will click on SAVE and then close the system completely down, including the interface and start again from a complete power off condition.
I have melodyne editor (ME) and it is probably, without a doubt the most CPU hungry plug in the stable.
As a result, I use some precautions when I work with it. I don't very often run multiple instances of it, as having it in two or more tracks at any given time. One track at a time. The second thing I have learned about ME.... it will crash and glitch the DAW from time to time when things don't flow correctly inside the box, and that will often result in a crash and subsequent loss of work. So I tend to work in manual correction mode, and I work on one line of the song at a time. I click SAVE when I finish that line, before moving to the next.
Most of the time, my system is rock solid and ME runs perfectly fine and smooth and causes no problems. However, when I do see that the system is not running like a top, whatever the reason, I'm always willing to click SAVE and reboot to a fresh start.
Clicking on the SAVE should be a habit anyway if you do not have the autosave feature turned on, which I do not.