orth noting that both the Audiophile and the UX2 can work in WDM mode, although the UX2 will lose some of its recording functionality.
The UX2 is a USB 1.1 audio interface.
As such, it uses a large hidden safety buffer (which raises round-trip latency) to help prevent dropouts/glitches.
If you monitor via the on-board hardware DSP, latency is low (like playing thru a POD).
If you try to monitor via software (to play thru 3rd party plugins in realtime), the round-trip latency will be too high.
If you monitor thru the onboard DSP, you can increase the ASIO buffer size to help prevent dropouts/glitches.
USB-2 audio interfaces (if you choose the right one) offer low round-trip latency on par with the best PCI/e audio interfaces.
RME are excellent for low round-trip latency, as are the new Presonus VSL units, and the MOTU hybrid series.
The Audiophile 2496 offers low round-trip latency (5ms at a 64-sample ASIO buffer size/44.1k)
If the I/O suits your needs, by all means, install/use it.
You can have both the Audiophile and UX2 installed... and switch between them as needed.
I wouldn't try running both simultaneously... as they each run on separate clocks... and will be out of sync.