How is your pc setup?
I ask cause this could be a shared irq problem ,or just something like buffer settings....
It is important to try to insure no irq's share with your audio device, that windows seems to like to do...if running win 7, you can no longer set irq's.
So the only way to get this done right before any software setup , is to use the bios and turn off redundant devices.
If you have a audio interface...type firewire/usb?...You do not need onboard audio....so you could turn that off in bois, freeing up that irq.
Also com ports if not in use can also be turned off.
What kind of mouse and keyboard in use? USB?...then perhaps turning off serial ports as well may help relieve some sharing of IRQs.
That said, ..setting up Win 7...tweaks?...turn off screen savers, and such sleep or hibernate features.
power settings , turn off monitor = never...advance settings Look into the hard drive tab and select to never turn off hard drives,
There are more setting to fiddle with...
After doing a check/setup on power managements profiles..save .
Setting up buffers/sample rates in software properly is dependant on bit rates you use I guess...
Someone else might have more to offer..