I have this interface as well, and am also running Windows 8.
Try the following:
1. Make sure the Sample Rate for the interface matches the Sample Rate as set in Sonar. I happen to have both set to 44.1
2. If using the 44.1 Sample Rate,try pairing that with an ASIO Buffer Size of 128. That's what I use, and I do not have any audio issues using those settings with this interface.
3. Presonus technical support advised that I go into Control Panel\Hardware and Sound\Manage Audio Devices, and for EACH available Presonus device (Line 1/2, Line 3/4, etc), that you go into the properties for each one, click on advanced, and make sure each one uses the setting that matches what you set the bit-depth for Sonar and the Sample Rate to. So, for all of mine, they are set to use: 2-channel 24-bit, 44100 hz (studio Quality). They advise this should be done for ALL Presonus devices, for both Playback and Recording under the Sound Devices.
4. Make sure you have the latest drivers from Presonus.
5. I had a bunch of trouble when I had the AudioBox plugged into a USB 3 port. Try using a USB 2.0 port for this audio interface.
I hope any of the above helps - I am now running quite smoothly and never have any audio issues using this interface with Windows 8.
Bob Bone