The Realtek Audio is your integrated sound device, but you don't have it enabled. The only audio device you have enabled is the Presonus Inspire audio interface, which is a good idea.
Let me look at your Audio Options tabs and see if anything pops out to me.
General Tab. Your buffer size is all the way to the left and if your audio interface/system can't deliver the goods you might be better off putting the slider near the middle and seeing how that works. You can keep adjusting the slider closer to Fast over time to see what works best for you. If it is too close to the left you will hear noise. Other than that it looks OK. Your device can handle 24 bit and you are using 16. There are some advantages to using 24 bit but that setting should have no effect on the problem you are having. Some people use 24 bit, some people use 16 bit. You can always change it later if you want.
Advanced tab. Nothing there seems off. You might try using the ASIO driver mode to see if that has any effect on your problem.
Drivers Tab. I see you have two inputs enabled. If you aren't using one of them I would suggest un-checking it if only to simplify your setup. You can't use the wrong input if it isn't enabled.
Your Project Options>Sync looks fine to me.
As far as your settings go, I have only two suggestions. First, try changing the driver mode to ASIO and see if that helps. If you stay with WDM/KS try moving the slider closer to Slow. Maybe around 10ms to start with and experiment with making it faster.
And anyone else who knows more about this stuff than me, please jump in and see if you can help.