@redbarchetta - welcome to the forum!
i have a ftu as well and have a couple of tips:
- turning off usb power management is essential, as mentioned
- run it at 48khz or 96khz 24bit sample rate - 44.1 doesn't play well for whatever reason on either of my systems
- running in wasapi mode is sketchy sometimes, so stick with asio as much as possible
- in preferences/audio/playback and recording uncheck "always open all devices" - this seems to be somewhat confusing with the m-audio drivers or something because when it's plugged in to a power supply more i/os are available than when running bus-powered. that has ALWAYS been a big hassle on my old lappy.
- in prefs/audio/config file set usewdmdmaforwasapi to false, allowofflinerendermixthreads to false, threadschedulingmodel to 2, minimizedriverstatechanges to 2
- if you have problems with audio dropouts, kick up dropoutmsec in the config file a bit
- never let your computer go to sleep. m-audio is known to bsod.
mine runs well even in windows 8 with windows 7 qualified drivers on any combination of usb connection - direct usb2, direct usb3, usb2>usb2hub and usb3>usb2hub. it's a fiddly unit no doubt (and that power connector is just so danged flimsy!), but i've used it live a lot and had no problems once i found the sweet spot.
have fun and hope to see you around!