I now almost never use the bin. I add al effects n the ProChannel. It makes it easy to change the signal flow.
You can simply drag the effect around to experiment where it sounds better. So, with amp sims, sometimes I compress before Amp, then EQ after, or compressor and EQ before, or EQ, then amp, then another EQ, then compressor, etc. etc.. You get the idea. The ease of use is was keeps me in the PC all the time now.