it totally works and can work well if you do a couple simple things
1. MAKE A BACK UP for when you lose the thumbdrive or drop it in the toilet.
the next points are all related the basics of SSD performance
2. don't keep more than a song or two on there at a time
2. thumbdrives aren't compatible with TRIM so the performance will severely degrade and more data gets written and deleted and copies and deleted etc etc.
2. I imagine that a lot of people with performance issues in their thumbdrive have used drives that had been previously used for shuttling files back and forth and with all the constant writing and re-writing, the drive is full of garbage. when you delete a file on SSD it doesn't delete it, it just marks the space that the file occupies available for rewriting. so when you start recording music, the drive wants to place your primal yawlp where your bootlegged movie used to be and it has to stop, erase that space, and then write your yalwp. so that is where the performance issue comes in. SSDs use trim so the PC is constantly scrubbing those spots clean for optimum performance.
so go ahead and do it. I use using a 32gb drive for a little while but at the end of a session, i'd copy the file to my network drive. I didn't skimp on the thumbdrive either. get one that is regarded for it's sequential write/read speeds; that's more important that random write/read speeds, IIRC.