CakeAlexS
To be honest with a modern computer and a fastish hard drive you can run the whole lot on a single partition/single fast hard drive without much issue. However having partitions reduces fragmentation of key files, and makes your backup strategy easier, plus it can speed up access, that is specifically in a single hard drive scenario. Looking at the speed and size of the other hard drives I would still recommend using the primary hard drive only for day to day work. Yes another faster hard drive to store data would be a better idea. A third hard drive somewhat overboard but you can never have enough hard drives. Personally I use four, but I actually only use two. I mirror my hard drives.
Fragmentation on a modern file system like the ones used by Vista, Windows 7 and 8 are not as much of a concern as they once were. On SSDs you never want to defragment it.
I have 6 HDs not counting another removable one for Vista.
It really doesn't matter how you set up, in that why you have them, or what they are used for. It, however, is better to have more than one.