For anyone new reading this, e turns effects off and on and that one scared the hell out of me when I first hit it by accident. All the Meldoyne instances dimmed out which is exactly how they look when Melodyne can't find its files! I thought I had lost 40 hours of work. (Meldoyne has lost files before so my fear was reasonable.)
Luckily it was just the pesky shortcut key thing.
So, attention newbies: "e" will turn reverb, Meldoyne, Guitar Rig, etc off and on all all tracks. Could be handy but also scary.