I have a akai MPK mini with one out, a usb to the computer.  There is no midi out.  I have a2i2 focusrite usb soundcard, no midi in or out on it.  I don't know why there is no sound, what is a midi computer with no midi out.  How do you make sound with it.  it seems as though nothing is happening. Randy Mader

Welcome to the forum Randy.  You aren't providing enough information for people to answer your questions, but hang in there.
 
Somewhere along the line, the output from your keyboard will be the input for a software synthesizer and the output of the soft-synth will be a sound card that is connected to speakers somewhere.  The keyboard is probably using the MIDI protocol over the computer's USB port. 
 
There is probably a host program somewhere that will handle wiring your keyboard to a soft synth.  Being as you are on this forum, I'm assuming that you have one of the Cakewalk programs for this (Sonar - Music Creator?) often referred to as a host or a DAW.  What software are you trying to use?
 
Glen

If I don't ruin my marriage on this deal.  we have an anniversary today of meeting. we have a sitter but I was planning on getting this done.  So I have already messed things up pretty bad.  Producer X1.  I am to the point to where I will need to walk away from this.  Till tomorrow.  I am also at the point where I need to hire someone who is an on phone expert who is available on weekends or hire this out.  I have to have things work to work on projects that are business related, I can't miss, it has got to hit.  When  I set down, got to work the first time.  In 10 years I will have a little more time.  anything else.  Now it is making midi movement on the software but no noise.  So I am lost.  Randy

Plug the keyboard into the computer.
Select a MIDI track and set that track's input to the keyboard.
Go to Insert at the top and select a software synthesizer.
Once the synth is inserted, set the MIDI track's output to the soft synth and the synth track's output to the Focusrite.
Play the keyboard.
Do you hear anything now?
 
There are extensive help files and several tutorials with your program, and thousands of videos on the net. Have you gone through the tutorials any?

Generally, the MIDI-keyboards that only use USB-connection usually/often also need a driver of their own. The ones with MIDI-connections are next to plug'n'play.

I have got it to the point to where the I am supposed to rout the synth output to the focusrite.  I have no idea what to do at that point.  I do not understand. this is ridiculously frustrating.  nothing.  junk absolute junk.  waste of my time.  I need help. I guess I will call cakewalk tomorrow.  this has been the most frustrating thing I have dealt with in a long time.  I have had lots and lots and lots of frustration but this is absurd.  thanks again.  

Ok what does it mean to set the synth output to the focusrite? I don't see anywhere on the track to do this.  

I changed usb jacks, it reloaded the drivers and then I showed levels on cakewalk but nothingthrough the speakers. (headphone jack of my focusrite)

this has something to do with routing-  the softsynth I have no idea what that means.  I am back to thinking the thing to do is set up a contract with someone who can work me through this stuff on the phone.  anyway, some advise would be awesome.  Randy

Specifically, what soft synth are you using?
When you inserted the synth, did you select the following:
MIDI Source Track
First Synth Audio Output (this one is where the sound gets from the synth to Sonar)
Synth Properties Page (this is where you select the sound that will be produced by many synths)

Do you get sound from Sonar at all?
Have you tried importing an MP3 or a wav file to an audio track?