Ive had similar probs even in X1 with this symptom.
To close out and re-launch X1 has been my fix. Not sure what the fix was for it.
Recently installed all new HDD and all software. Not sure if I loaded the same MAudio driver that I had before but I havent experienced it since the repairs.
But closing and reopening was what I had to do.
If I recall I could duplicate it by adjusting any memory intensive plugs or adjust ProChannel while the Transport was in motion. All meters and indicators showed music playing, just no sound out of monitors.