It seems to only be happening on an old project I was working with this morning. so I guess it's just a weird bug in that particular file. I tested it out on a different project and didn't have the same problem. /shrug
As far as the buffer, RPro is unusable for me at anything beneath 192. The audio glitches are just too bad and I'm afraid I'll blow a tweeter. I've also found several patches with missing multisamples, so I'm suspicious that there is something else going on here.