I had pops and crackles when creating mixdowns after reworking an old project which contained a Korg M1 Digital soft synth. I still haven't sorted it out after hours of trying. That synth needs re-licencing after upgrading to Win 8. I'm thinking that there may be some kind of timer running on it and causing the problem
Working in new projects with imported audio is fine. But I haven't tested a mixdown yet.
My buffer is 256. Q660 Win 8 32 bit, 2 Meg