I was going to say what Sharke said: If you don't HPF the guitars and bass (at different frequencies), things will get muddy quickly.
I also filter and boost kick and bass at different frequencies. That may not sound like a guitar mixing trick but it does help clear out a space for each thing.
Starting points (for me): cut guitars under 150 hz. Cut bass under 50-60 or so (depends on the bass). Notch out the kick (cut it with a fairly narrow Q) around 300 or so. Some people also boost the bass at 300 to complement the kick, but the basses I use don't need that and 300 is a very muddy area. The kick thing varies a lot, but I am pretty rigid on low-passing the bass and guitars.
If you guitar sounds boxy, cut a little at 800. If it sounds dull, give it a little air between 10K-12K.
I also find that too much effect (like too much drive/distortion or too long a delay) gets kind of messy in a mix even though it sounds awesome solo.
I use in-your-face sounds without layers in general, but for your style of music, layered guitar sounds panned in stereo are common.
Also, and this is weird, I have had better luck with Guitar Rig on Strats than on Les Pauls, even though I love Gibsons. That is probably a gap in my knowledge or experience and not the fault of the software.