I did my research and picked the Saffire PRO24 DSP specifically for it's features and because I wanted a Firewire interface - ostensibly for it's stability and low-latency. I was never able to get it to work without frequent, no, *constant* pops and clicks and glitches. It drove me crazy. And yes, I did all the usual trouble-shooting steps. My SiiG FW card had the recommended TI chipset. I did all the registry hacks and settings etc. No joy.
Frustrated - I bought a Roland Quad-capture for $160. I downloaded and installed the latest drives, hooked it up, started using it. I have not had a single pop or glitch or dropout. Projects that glitched every 10 seconds play cleanly. Yay, I suppose except I still wish the Saffire worked - I really liked the preamps, I can use the 2nd headphone out and I found the VRM stuff really useful.
Oh well - playback and recording stability win out (lower latency too, over USB, go figure).
That is all.