I've been mixing with headphones for about 7 years. More often than not it was very difficult to get my mixes to translate well on different speakers. Sounded great in the cans, but terrible on PC speakers or in the car. Got it to sound good in the car, then my stereo's Infinities sounded like crap. And on and on.
Started using Sonarworks Reference and like magic my mixes began to translate better on all the speakers!
The calibration really does give a much flatter frequency response, therefore there were no more frequencies building up or getting lost.
My $.02, buy it, use it, you won't regret it.