what axiom ? v1 or the later white ones ?
you can look here regarding setting it up.. there are x-amount of thread about it..
but you might wanna try setting ya base octave to -1 in pref's :) DEPENDING on the synth you use and what not they are triggering..
remember m-audio were "in" with propellerheads... to a point where I had to wait a month *AFTER* release along with 400 others to get v4 , thanks to m-audio's WOEFUL distribution of it
there is a setting you can use in reason, in the midi patch part of it IRC. not been using my axiom rewired for a while , so a bit rusty.