If you are already running Windows 10, and have the correct drivers installed for your audio hardware setup, the motherboard and CPU change should not upset the OS.
I have not tried this yet, but have heard reports that Windows 10 has a newer method of abstracting hardware, where the motherboard and chipset changes are taken in stride now. Where in past versions, it used to take a sysprep or a repair install to get the OS working on the new hardware, it should no longer be necessary.
The digital entitlement for the Win 10 license should still be good as well.