One truly Bizarre thing I found with both my M-Audio Keystation Pro 88 and MIDISport USB 8x8 MIDI interface. If they were plugged into USB port next to my USB Mouse, as you know USB ports are often paired on PC cases, the MIDI device connected would just lose connection with SONAR after some indeterminate time.
All the usual power management had been set, and the suspend disabled but still they would just stop working.
My solution is one device per pair of USB ports since I adopted this approach I have not had a single dropout.