Ok, so I recently purchased a new computer from ADK (excellent machine, stats below) and I transferred my old projects folder from the old machine to my audio drive on my new machine. These are per-project folders. Some of these projects were recorded @24/48K, and some @ 24/44.1. My new "Preferences" settings for Bit rate are 44.1 Khz. I opened an older project that was 48K bit rate and started having problems with the audio engine stopping, and had to reboot to get it going again.
I've only been using a DAW for around five years, and I'm not that knowledgeable with computers. I've learned a lot, but I'm not sure if it matters if a 48K project is opened when the preferences bit rate is set to 44.1K. I researched the help files, searched this forum, and cannot find an answer. Will someone kindly educate me?

Thank you.