tlw
I've come across people on forums who have only used sims then finally got a real JCM or Mesa who complain their amp is broken because it doesn't have the "killer distortion" of the emulator's version of that amp.
Most of those people have what is called a bad ear, tainted by the use of Amp Sims.

But seriously though, I don't know anyone who owns a JCM, Plexi or Mesa Boogie that prefers Amp Sims over the real McCoy (unless its necessary for late night recording, scratch track ideas).
Amp Sims have come miles in just the past 3 years alone. But they can not and never will be better than the real thing. I own many amps, microphones and speakers (for different head/cab combinations) and I have yet to find an amp sim that replicated the sound of tube break up like a real JCM800. Positive Grid Bias comes pretty darn close but just like sampled drums, I will always take the real thing over a modeled amp.