Most orchestral libraries are already pre-panned according to the traditional stage arrangement, so further panning isn't necessary -
if, of course, you are content with the traditional form. Hollywood film scores don't conform to tradition, nor do pop/rock orchestral backing tracks, so there is plenty of precedent for violating tradition. Personally, even though I tend to stick to conventions, I have no ethical qualms about panning basses to the center.
Front-to-back positioning, however, is usually up to you. That means adjusting send levels to the reverb bus for each section to simulate their distance from the listener.
Whether you're going full classical or modern Hollywood, there will be times when you do have to position an instrument yourself. For instance, in an acoustical performance a solo instrument will normally move to the front and center of the stage. In that case, you'd pan it center, reduce its reverb send, boost its treble and turn it up. (Don't forget about the role of EQ in creating the depth illusion.)
My biggest challenge is with reverb. Because I often mix and match libraries, it takes some trial and error to bring dry samples' reverb up to match the more ambient samples while maintaining the front-to-back illusion. Sometimes I have to resort to multiple reverbs if the disparity is great.