That fixed it. But I don't understand why. Why can't I send the midi outputs out one port and the audio out another? I was able to get away with this under Home Studio 4 (after a lot of struggling.)
I'm still in the dark on ASIO. When I get to Driver Settings, I see no mention of ASIO. And what I do see is rather confusing. I've changed my Audio Driver Bit Depth from 16 to 24 since that's what the US-144MKII outputs.
I'll try checking the 64-bit Engine option since my machine is 64-bit.
Dim solo gain makes little sense to me, I've left that at -12dB.
Sampling rate I've left at 44100 though the Tascam does up to 96KHz.
The mixing latency parameters are set at buffers = 2, buffer size = 1364 samples, 30.9msec. I'm hesitant to goof around with these, as I'm not sure how I'd test whether I've had improvements or not.
For the record, the wave profiler showed me:
==== TASCAM US-144 MKII (2 in, 2 out) ====
11025 Hz: not available
22050 Hz: not available
44100 Hz: Channels 1,4 -- Bits 16,24,24(4 bytes),32 -- OK
48000 Hz: Channels 1,4 -- Bits 16,24,24(4 bytes),32 -- OK
88200 Hz: Channels 1,4 -- Bits 16,24,24(4 bytes),32 -- OK
96000 Hz: Channels 1,4 -- Bits 16,24,24(4 bytes),32 -- OK
176400 Hz: not available
192000 Hz: not available
384000 Hz: not available
==== Realtek High Definition Audio (3 in, 6 out) ====
11025 Hz: not available
22050 Hz: not available
44100 Hz: Channels 1,2 -- Bits 16 -- OK
48000 Hz: Channels 1,2 -- Bits 16 -- OK
88200 Hz: not available
96000 Hz: Channels 1,2 -- Bits 16 -- OK
176400 Hz: not available
192000 Hz: Channels 1,2 -- Bits 16 -- OK
384000 Hz: not available
So, what's my point? This stuff is pretty technical and somewhat confusing. Discussing it here is proving to be helpful.
Thanks much to those who have spent the time to respond.