The problem with awaking from sleep/hibernation is bugging users since the introduction of these modes. Some hardware/driver combinations do not like to sleep. F.e. my wifes PC (old Via chipset) build-in Ethernet not only does not like sleeping, it does not like QuickBoot...
You can find endless stories about problems with audio on notebooks after sleeping (with fancy variation, like "does not work after sleeping if I forgot to pull our my headset before...").
Sometimes massaging power/sleep options or downgrading/upgrading drivers helps, but most of the time people just accept they can not use sleep/hibernation/quick boot on particular system with particular OS and drivers.
Note that with Firewire, not only audio interface but also the Firewire interface card can be the reason.
Problems with the mode switching, which we just avoid by matching Windows settings, indicates that your Focusrite is already on "thin ice". I have the same with my old M-Audio Firewire interfaces, one step left or right and the system BSOD in m-audio driver... But if I "stay on the road", then everything is fine.
Leee
Continued from previous post ^^^^
Do you think one of the options in Exclusive Mode needs to be unchecked?
No. You want some applications are able to use exclusive mode.