I know you listed some things in the original post, but you have done a system restore, and I am not sure how things are currently set on your system.
1. What is current driver mode set to in Sonar?
2. Are interface drivers installed in Wind 7? What specific version?
3. What is default audio device for your system set to for Windows?
4. Have you tried going into Device Manager and disabling the Realtek audio?
5. Does Device Manager show your interface under Sound, Video, and Game controllers? Does it show as working properly?
6. Have you checked on Firewire compatibility issues between your computer's Firewire chipset and your interface? (run OHCITool.exe from Focusrite:
http://www.focusrite.com/...r/attachments/OHCI.zip )
Please review and respond to all of the above. It will help us to help you,
Bob Bone