Interesting. It has never even occurred to me to save a project I've opened in safe mode. That's always a troubleshooting step, to see if a problem is being caused by a plugin or not. And because the next step is usually to remove plugins one-by-one, I always start by saving the project under a new name.
At any rate, safe mode isn't your best solution. If projects are taking a long time to load, first make sure you're not doing an automatic plugin scan - that can add an extra minute right there. More likely, it's just large sample libraries that are slowing you down.
I do have some large projects that take up to two minutes to load. 5-6 minutes is pretty extreme, and
might indicate memory exhaustion. I say
might because 8 GB will hold a bunch of medium-sized libraries and a couple monster ones. After they've completely loaded, check your memory usage. If they're Kontakt instruments, it'll show you right there in the header how many mega/gigabytes each instrument has loaded. Other samplers have other ways to show you how much RAM they're consuming, and each has its own tricks for deferring loading or minimizing memory usage.
If you've got one or two monster libraries (e.g. OTS Rick Bass, the reason I was compelled to give up XP and go 64-bit in the first place), consider freezing them. Then they'll pop right up, no loading required. Even if your template has no MIDI data you can still freeze the tracks to avoid loading the library on start up. Un-freezing is a one-click operation. Freeze them all and save that as your template. When you start a new project, just un-freeze the ones you want to use.
It works for food, too.