I often use the CW amp sim. Sometimes more than one instance.
EQ before and after, modulator, compressor, impulse reverb,..
Sometimes 2 buses with amp sim in both,...
It is very versatile. And easy to use.
I start with splitting the guitar signal with a DI, record the clean signal, and then record the stereo out of an epiphone amp with lots of variables for the 2 channels, and some chorus.
Also got a '54 gibson amp. The guitar into a ''71 wah-wah/booster pedal, into the gibson, way loud in the basement, gives a great moody blues tone.
Sometimes use the re-amp box, for guitar and other instruments.
But, internally, the CW Amp Sim is my little friend.