Also disable Speedstep, C1E in the BIOS. In fact, disable everything in your BIOS or Windows that you don't need!
Presonus has a nice, thorough guide for optimizing your DAW. Seems appropriate to follow it since you have a Presonus interface:
http://support.presonus.com/entries/119099-optimizing-your-computer-for-audio-windows-vista-windows-7 Take the time to read over everything. You may not need to tweak every area, but try not to miss something that might be important. If you're not sure about anything, post back and ask here.
If you bought a brand-name PC, likely it has a bunch of junk software pre-installed. Remove everything in registry startup that is not critical (Use regedit or a startup utility for this). **This, more than any other step, goes overlooked by many users, yet is the most likely reason they have problems (IOW, don't assume that, for example, your motherboard software installed a monitoring utility, so it must be okay. For audio purposes, it is not --so get rid of it!).
Good luck!