Bob is correct and confirmed by Presonus support. There is an issue with their 1.2 AudioBox drivers and USB 3.0. They have addressed this in their forthcoming 1.3 release. This issue may apply to anyone's specific hardware/driver, so rule out USB 3.0 first. FYI, Using a 128 ASIO buffer size in X2 to match the AudioBox settings in Control Panel has produced a very favorable result of 7.8ms RT. That I can live with

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The Presonus AudioBox 1818VSL is a hot item right now. GC has a waiting list for them. Luckily I got mine from one of the San Diego stores. What I like about this unit is that it has it's own set of direct driver plugins (aka FatChannel) that has a Filter (phase), Noise Gate, Compressor and GEQ for mixing "Live" sound and I can record to the DAW (X2) without worrying about RT latency. This has been my "So called"..."Quest for the Holy Grail". Now I can save my back and decrease my setup time by not having to lug around a 32-channel mixer and a 10U rack of EQ's, Compressors, FX, etc. What I may elect to do is keep my FOH EQ (Behringer DEQ2496) and Crossover (Behringer DCQ2496) in my 6U rack with the AudioBox. Always a work in progress, eh?
Anyway, this forum is about X2 so I don't want to get off track too much. So with this configuration, I can send a multi-mix down to X2 dry to record the live gig and add the effects, etc later for post production final mix.
Thanks to everyone who contributed to this thread. All good stuff!!
robert_e_bone
+1 on registry manipulation cautions.
For Gio's situation, no registry entries were harmed during the process of solving his problems :)
It just doesn't like USB 3.0 ports in the driver's current form. They are in the process of incorporating changes to their drivers and will hopefully fix that in the next Presonus driver release.
Bob Bone