As above you sound like your cliping the signal before it is converted.
1-Set the Mackie to get a good "safe" level. A compressor inserted on the channel would be ideal.
Set the gain on the Channel so the peak light only flickers at the loudest input.
Set the master output at Unity. Observe the meters.
2- Use a line input NOT a pre amp input on your interface.
If it has a peak indicator observe it's status.
3- You need to completely disable any Soundblaster audio devices from you computer or you will have issues, this is documented over and over on this forum--Creative = Problems.
4- Make sure you have the latest ASIO drivers for Windows 7 64 bit from your interfaces web site.
5-Check the 64 bit engine