Glad to see people enjoying MixIR2. :)
To me it's
the one constant on my guitar tracks, whether I'm using Amplitube, GR or pretty much any other amp sim, hardware and software. The ability to use and mix up to 6 different impulses at once PLUS the ease of use make it one of my most-used 3rd party plug-in. Of course, there are alternatives, but I've stopped looking after I've tried MixIR2.
I don't have the HD500, but I've used the RedWirez impulses w/ my older Pod a lot - bypassing the cab sim on the Pod. I just felt that the results were more lively.
These days, I don't use the Pod that much - in fact, it's been stored in a warehouse somewhere w/ the stuff I rarely use since we left NY.
I rely on software amp sims exclusively - since I've included a little DBX hardware compressor to my rig for that specific purpose, it helps me prime the signal a bit on the way in and add a little edge which I felt was missing.
As such, my signal chain consists of DBX compressor - software amp sim w/ cab bypassed (that's the variable) - MixIR2.