Cakewalk tech support said to use MME and I'd already followed the advice here:
http://www.cakewalk.com/Support/hwsetup.aspx?dm=alesis&man=Alesis Tech support also said IO2 ASIO drivers are not "true ASIO", just shims around the MME driver.
Wrt to hijacking, I picked this thread because it seemed to be about exactly my problem and some forums like you to show you've read past postings first and discourage starting unnecessary new threads. I don't care, I can do either. I think of hijacking more as drifting off topic on a thread.
Tonight I ordered a Tascam. Maybe it will work better. I flailed trying to get Alesis to run reliably without dropouts so who knows, I've probably ended up with some obscure non-default setting. Worked fine with the Cubase demo that came with the IO2.
Computer-based recording is awesome when it works but my old Fostex 8 track had certain good points.