It is true the best way to troubleshoot is by the process of elimination. Pretty hard to do with our DAW setups as this involves trying a different computer, different DAW and a different audio interface.
Well the computer I can do as I have 4 or so kicking around, most people might not have that option.
The DAW, well it's never the DAW so forget it..
I have 4 different audio interfaces kicking around which help me figure stuff out pretty quickly.. It will answer the question of where to place the blame.
So that is something you might want to try. Is there a music store you can go to. Most will happily let you try gear for a few days.