Worst:
Alesis 1622 mixer: least transparent mixer I've ever used (and not a pretty coloration), plus super-cheap construction ... hated it!
Alesis Midiverb II: didn't sound terrible, but noise, noise and more noise made it useless for pristine recordings
Alesis MEQ-230: again, cheap construction, barely adequate performance
(sensing a pattern here?)
Best:
Mackie CR/1604-VLZ: replaced the Alesis mixer with this. What an amazing trade up it was ... and for almost the exact same price!
Korg Wavestation EX: this instrument has been at the centerpoint of my music and my studio setup for 15 years now and running.
Bass Collection electric bass w/active electronics (don't know the model #): bought it on the cheap from a friend who was looking to unload a few of his extras (he was into Steinbergers at the time). He wanted to buy it back from me a few years later ... but sorry, I wasn't lettin' go of it, it's too awesome. :)
And many versions of Cakewalk for DOS, Cakewalk Pro Audio, and Sonar, of course.