Best:
Ableton Live - Sonar Pro is great for my heafty and final builds but to throw down
creativity nothings better, dare I say even P5
Reason - can't beat the compressed format for sounds on a laptop and since you can
only have Sonar on one computer....
Motu Ultralight - Transparent Pres and, great GUI, Live mixer, low latency........get one!
Line 6 - Variax, Podxt Live: I'll agree that all digital will never sound as good, but the
flexibility, sound design, & gigging win.
Novation SL-Zero - Phenomenal, how did I ever interface without one, nuf said.
Stylus RMX / all Sage expanders - You can't get better sounding drums, check out
Skippy's Noizebox!
Atmosphere - again you just can't beat Spectrasonics for overall sound quality
Hercules Stands - look cool and built stage worthy
Worst:

Motu Mach Five - 8 gigs of useless sounds, frustrating reformatting,
Pro Tools - MBox 2 - the MBox 1 worked great, could never get MBox 2 to work, Digi's
are a little too proprietary for me
Built a custom PC and didn't get an Istar D series rack case - just ended up getting one
later
SoSo:
Dimension Pro - Great sounds I just haven't really used any of them on projects - a little
too other worldy for me perhaps
Project 5 - Could be amazing, but you can tell Cakewalks money is going elsewhere -
needs GUI update & hardware (like Torq)
KRK RP-6's - For the money they are a great buy...but then you hear dynaudio
BM5a's......absolutely no comparison!