I'm surprised no one has mentioned a custom built computer or Omnisphere...
Cake ought to be proud many list Sonar...but it ends with 7PE... ha! (makes me wonder about upgrading!)
my bests would be:
JBL 4311 monitors bought 30++ years ago and later a set of Auratones.
SuperVee trem system on my Strats, replacing Leo's piece of junk. Better than any Floyd too.
CD architect
My Echo sound cards - Gina, Layla 20 and now the 3G
Roland XP50 (now have a JV2080-loaded w/expansions and a XP80 too).
EZD morphed into Superior 2.
Sony MDR 7506 headphones
worsts:
Just crappy, low budget equimpent, like an Alesis guitar amp, Art rackmount digital FX, cheap guitar pedals - basically all lured by low prices and taking a gamble. Not to say a SM57 (etc) isn't rated high, though.