I have now upgraded my office system to the tech preview - of course, I'm not running Sonar or other music apps there, but I can say that so ar with the latest 10074 build, it's running smooth as silk as an in=place upgrade from 8.1.
Of course I know that it is recommended not to do this, but I am ok with the risk, since IT is my game anyway, and I have a fully functional Surface and other systems around that run just fine. I also have a VM that I could load up anywhere that is running the apps I need, if I had to go that route.
Now I wait until the Editor/Roland drivers for the PCR-800 come out. It's the only thing on my music system that didn't like Windows 10 at the time of the January build. Maybe it's changed since then, but I'd rather not take the chance, as that pcr-800 has no wall wart (here) and doesn't even get power from USB without the right driver, so I can't even use it as a regular midi device with a different midi interface, which I have - and works under 10.
I wonder why the Roland driver is SO particular about not working, when even devices like the Line6 UX2 and Layla 3G are working under Windows 10 just fine with Windows 7/8 drivers.