If you can, put the synth files on the SSD. You'll get much better performance.
If you can't, install the OS on the SSD and install your synths on another drive.
I have mine set up drive C: is the OS and programs.
Drive D: is for the VSTi
Drive E: is for the audio data
Drive F: is for BU and storage.
I don't have an SSD but if I did, it would be the OS. If I had a second one, it would be the VSTi drive.