So once again, like I said in the other thread ,, midi drivers are important! So what happened to you was your USB midi drivers, if there were any to begin with, were pourly written, and just like a pourly written audio driver you get sync issues. You switched to your audio interface which has proper midi drivers, problem solved.
You should never have to mess with manual offset adjustments if the audio or midi driver is doing it's job.
I have a feeling this is another W10 issue where we find a lot of gear now doesn't come with drivers for W10. The web site will just tell you that W10 will deal with it and use a generic driver.
I just ran into this with a Printer I have that I use for CD printing. Worked great with XP and W7 because it had a install disk, It won't fully work under W10 because W10 rejects the Install disk and installs a printer driver it downloads. Problem is there is no driver to make the CD printing tray work under W10. The Epson web site say's the printer is supported by W10 but say's driver will be automaticly installed so no software on the site.
I also had my G force Video card stop running in dual screen because w10 had overwritten the factory driver.
So this song and dance is true of many manufactures who don't take the time to update drivers.