I've been using a 40" 4K monitor for about a year now. Will never go back to anything smaller or lower res again. The nice thing about a 40" 4K monitor is that it has the same DPI and number of pixels as 4 x 20" HD monitors. So you don't need to use a magnifying glass to read the text or worse, use > 100% text scaling (which many apps still have problems with). This feels like having a full size mixing console on the screen when I run SONAR, pretty nice!
However, there are two important aspects to look at when getting a replacement monitor. First, make sure the monitor has 4:4:4 chroma subsampling. Anything other than that and you will get blurry text. For a TV which has soft lines, this is fine, but for a computer monitor where you have sharp edges, you must have 4:4:4. To verify a monitor has 4:4:4 chroma subsampling,
check the instructions here.
The second important aspect to check for is to make sure the monitor doesn't use PWM (pulse width modulation) to control the brightness of the backlight. Even if it refreshes at 240 Hz, it can still cause eyestrain. The reason is that it tricks your eyes into being unsure exactly where to focus, so your eyes keep re-focusing but can't quite "lock on" due to the flicker. This causes your eyes to feel tired after a while. Once again, just because it refreshes at higher than 60 Hz and you can't actually tell it is flickering, it doesn't mean it isn't causing eyestrain. To test for this,
use this link. The lines moving across the screen must not have a strobing effect. If it does, it means your backlight is using PWM to control brightness.
[EDIT] The chroma subsampling problem is probably less likely to be an issue on smaller dedicated computer monitors, but if you go for 40", many of those "monitors" are rebranded TVs where you have a higher chance of getting something other than 4:4:4 chroma subsampling.