As someone who has come from Win 98 to Win XP and now Win 7 I must say I am not hearing any major differences at all. In some case projects were migrated over the OS systems and still no major difference either. If they are handling audio differently then I am certainly not hearing it. In any major way that is.
I also run Studio One on a Win 7 machine and an iMac and also not hearing any differences either. Not only with the same interface on either but even with different interfaces being involved.
That is the cool thing about digital. It has amazing uniform consistency. Unlike playing back the same 2" reel to reel multitrack on a raft of different machines and through totally different mixing consoles. That represents the opposite.
I think you may be suffering from a dose of mis information on the net syndrome. There are far more important things that are going to influence the quality of your production.