Alcohol has never agreed with me. I can sort of appreciate that one drink buzz but anything more than that just makes me feel like crap. Not necessarily sick - that doesn't come until 6 or 7 drinks - but just kind of wired and emotionally blank. I don't think that's the "normal" reaction to alcohol but it's certainly mine.
I hear other people say two things about alcohol that are the exact opposite for me. Firstly that it helps them get to sleep - if I have so much as one drink it takes me hours to sleep, I just lie there with my eyes wide open. Secondly that it makes them feel frisky and enhances sex - again, so much as one drink and I am completely and utterly incapable (and unwilling) on that score
"Herbs" have the proper desired affect on me, but I'll only partake in that once in a blue moon. Any more frequently and my daily motivation tends toward the "eating cereal and watching cartoons" side of things.