kday
mettelus
Windows has never been elegant about coming out of sleep or hibernation. I suspect that you also have USB ports enabled to go idle. Disable sleep/hibernation and the power management on the USB ports and your interface will probably function fine. Drivers do not unload, but the USB port will go offline unless that functionality is disabled.
How do I disable USB ports, is that the same thing as disabling the hibernation or sleep mode?
Sorry for the late reply, but Leadfoot got the gist. In Win10, if you type "Power" into the search box, select "Choose a Power Plan" from that list, then "Change Plan Settings" for the selected plan. Next screen select "Change Advanced Power Settings" and in that pop-up, expand "USB" all the way and DISABLE the "USB Selective Suspend Setting"
While in there, I would also disable sleep/hibernate (just above it), and do a quick check of that list for anything related. (E.g., hard disks never shut down plugged in, "Minimum Processor State" 100% when plugged in, etc.) Even if on a laptop, ALWAYS run in DAW-mode plugged in, and do not let anything sleep/hibernate/power down/throttle.
As a side note, if this is your root issue, you could check before doing the above by disconnecting/reconnecting your interface after a sleep cycle. This will force Windows to reconnect that USB port (an the AI should come back online).