I have been plagued with small timing issues... guitar parts being out of time by 1/16 note or so.  Not sure I can pinpoint when this started happening.  
 
Take a second guitar part for example.  It has just E&A two tone played for 1/8 note pairs on beats 1 and 3 of each measure for a bit.  
 
I listen to what I recorded and it is routinely ahead of where it is supposed to be.  
 
I know I am getting old, but my chops are not that sloppy!
 
I have my audio prefs set as shown..  Latency looks high, but wouldn't that delay rather than rush a beat?
 

 
 

This is not my area of expertise by all means, but check your buffer setting on your sound card.  Click the "ASIO Panel..." and lower it 128 and see if that works better.  When you are mixing you will probably want to raise the buffer setting to as high as 1024.  With all the new plugins that have look ahead features I think timing might be wanky.  Do you have a VST plugin that looks ahead like the LP MB in your project?  
 
I recently noticed a similar issue with midi on my RME sound card.  Everything I played was ahead of where I thought it was played.  I've read that it is an issue with RME cards and there is a .dll that fixes things, but I picked up a $14 usb midi adapter to by passed my RME card and timing is fine now.  Not sure if that applies to your situation, but gives some insight.

had the same problem for months
have to do a work around

Make sure that "use reported latency" is checked in Preferences/Sync and Caching. Then do a loopback test. It is possible (likely) that you also need a manual offset.

Where would I put a manual offset in?  Would i still hear things played in sync?
 
I am trying to figure out if I hear things on VST synths.  I am not sure I can tell a constant ~1/16 note offset.  A guitar attack is very sharp.  And while I can play 1/16ths on a guitar, it has to be the same note over and over on a keyboard!! (hahah).  But again, looking at the midi, it looks to be slightly early too.  

I would try reinstalling your UAD drivers.
15 Sec is very generous roundtrip. you shouldn't be having any issues there with 15.

Manual Offset is in Preferences/Audio/Sync and Caching.
 
To do loopback test:
First, record a click to a single audio track in an otherwise blank project . Any audio file will do, but a click is the easiest to line up later.
 
Second, patch your interface's audio output to an input and re-record the click to a second track. If the waveform of the second track lines up in time perfectly to the first, then you are the one with the timing problem. If they do not line up (as I suspect), you will need to experiment with manual offset until a recording of the second track lines up precisely to the sample.
 
If you have not performed this test you do not know for certain that your audio recordings are accurately synchronized. BTW my manual offset is 98 for my Orion 32+ with a 44.1k sample rate. If you check the box "use reported latency" then the manual offset should stay the same regardless of the buffer size.
 
If your issue is with timing of midi recordings, that is a different problem. Midi timing offset is global and can fix timing on input but it screws up the output timing so it is better to just nudge new midi recordings by the offset. You can determine the midi offset with the same type of loopback test as above (with a midi cable instead of audio).
 
hope that helps

Well I don't know how Space Cowboy is doing with his issue,  but my midi and audio timing is dead on now.  I really do like this forum.  Interesting thing...I did tests with two different metronomes.  One external and one internal.  The internal metronome was dead on once recorded thru my sound card,  the external was a hair late-ever so slight-off the beat.  I'm going to guess that was due to midi being involved.  The funny thing is I played the same exact midi piano part 2 times with the different metronomes to see if I could determine which way resulted in the best timing.  There was no discernible difference what so ever.  Even tho the external metronome is somewhat off (maybe not detectable to the human ear).
 
Anyway ...Thanks!!
 
 

Base 57
Maybe the culprit is these &*#^ Magix drivers.  I installed Sound Forge 12 the other day.  It took over my drivers under Audio/Devices in Prefs.  I fixed that.
 
But it is now showing up in the Sync and Caching.  
 
I tried switching back to my UA drivers, but SPLAT keeps defaulting back to the Magix.  I cannot undo that.  
 
Is there a driver cache somewhere I can edit to remove the Magix?  
 

Oh for reference, I got the UA drivers in this page.  the yellow highlight is no longer the default.  
 
Sorry for the sloppy red.  Hard to draw with a wheel mouse.