I'm using the Solo Voices option with Nectar 2, and these days I'm automating a Send to trigger it.
I only use presets to audition harmony combinations in order to find out what might work or sound good for a song.
(If I remember correctly, I output from the Nectar bus to another bus where I Fx just those Harmony voices. Otherwise, I believe Nectar will apply its Fx to the original vocal too. I could be wrong about that though, if the Harmony module is first and the Solo Voices option is on....)