batsbrew
there was always a 'room of doom' that had such terrible acoustics, that nothing could be done,.
i say, if the PA sound bad, it starts with the soundman,
sits in the middle with the quality of the gear,
and ends with the room acoustics.
2 of those you can fix.
I think Batsbrew has it spot on here. I am lucky enough to live near a venue called The Stables Theatre in a village called Wavendon just outside the city of Milton Keynes in the UK. It is run by the singer Cleo Laine and was managed by her and her late husband the musician Johnny Dankworth. The main room is a 1500 seater auditorium called the Jim Marshall Theatre which has the perfect combination of great equipment, sound engineers and most importantly, was designed and built totally for acoustic perfection. I have been to many many shows here over the years, from solo singer / guitar to full rock performances at thundering volume. In fact, the last two gigs I have attended there cover both those extremes - Nick Lowe, and the classic 70's rock inspired prog rock band, Mostly Autumn.
The sound is never less than stellar, world class artists love to perform here, even putting it on their tour itinerary when they are selling out far larger venues on the same tour, and mainly because of the acoustics.
So, to answer your question Bit, I believe the venue has to be sonically designed for the task, which is a rare thing, and therefore PA sound becomes a hit and miss affair...
EDIT: For those interested in the UK -
http://www.stables.org/ - If you plan to see an artist or band on a UK tour, it is well worth the extra mileage to book here - but you have to get in early...