Just to chime in. after much debate I finally went from win 8.1 to Win 10 Pro. I have some really old software. Like Guitar Power, which is a chord dictionary of sorts. works perfectly in 10.
My Roland Sc-88vl works fine with win 10.
I also have an echo Layla 3G pci based audio interface.
After advice from the forum I would up buying a $27 PCI to PCI-e adapter for the echo PCI card. Works perfectly.
There are new motherboards with pci slots but most do not have any. I figured I might as well go all the way. Got the Asus Z370 Prime A MB...Killer MB.
BTW, I actually have 2 of those AP2496 cards. In my closet at the moments. They always served me well.