I would love to, but there is not enough rotaries on the VS-100 for my liking (just the four at the upper left + 1 push button). After mapping it for the Pro Channel I finally gave up since it simply wasn't enough control. I had to use the mouse to get at the rest of things - so might as well do it all with a mouse.
I know there is a way to set "Full DAW Mode" which converts the entire left side to be assignable. This would be enough buttons/knobs, etc... for me - but they are not endless rotaries, so I couldn't be bothered. Besides - I use the mixer section of the VS-100 for many other things in my studio so I don't like losing that.
My primary VS-100 use is as follows.
1: Audio Interface, In/Out
2: Transport for DAW (not just Sonar) and basic functions (solo, mute, arm, track select, etc...)
NOTE: The Footswitch option is a must for me as a guitar player. I made a custom footswitch. A black button to control start/stop and a red button to control recording in/out.
3: Comp/EQ when recording. I use it all very gently, but I do use it on almost everything.
4: A small 6 in mixer for my project studio. Along with my patch bay I have access to every device in my studio.